1Univ. of Maryland, College Park (United States) 2Wellman Ctr. for Photomedicine (United States) 3Massachusetts General Hospital (United States) 4Harvard Medical School (United States) 5Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States) 6Marlene and Stewart Greenebaum Cancer Ctr., Univ. of Maryland, College Park (United States)
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Combination treatments are most effective when targeting different cancer survival and growth pathways. Nanotechnology combined with photochemistry provides a unique opportunity to simultaneously deliver and activate multiple drugs that target all major regions of a cancer cell—plasma membrane, cytoplasm, and nucleus. In this study, we developed a light-activatable nanocomplex that selectively and simultaneously deliver three clinically relevant therapeutic agents at a synergistic drug ratio to destroy ovarian cancer cells, while sparing normal tissues.
Barry J. Liang,Michael Pigula,Yan Baglo,Daniel Najafali,Tayyaba Hasan, andHuang-Chiao Huang
"Rationally designed light-activatable nanocomplex for multi-tier cancer cell targeting and photochemotherapy", Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2609687
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Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali, Tayyaba Hasan, Huang-Chiao Huang, "Rationally designed light-activatable nanocomplex for multi-tier cancer cell targeting and photochemotherapy," Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2609687