Ultrafast laser surgery probe for vocal fold restoration: ablation performance on ex vivo porcine larynges

Liam P. Andrus; Hamin Jeon; Michal Pawlowski; Tomasz Tkaczyk; Adela Ben-Yakar

doi:10.1117/12.2608361

7 March 2022 Ultrafast laser surgery probe for vocal fold restoration: ablation performance on ex vivo porcine larynges

Liam P. Andrus, Hamin Jeon, Michal Pawlowski, Tomasz Tkaczyk, Adela Ben-Yakar

Proceedings Volume PC11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022; PC1193505 (2022) https://doi.org/10.1117/12.2608361
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We present a miniaturized ultrafast laser surgery probe for vocal fold restoration therapy. Previous benchtop studies have shown that sub-epithelial voids can be created within scarred vocal folds via ultrafast laser ablation to improve the localization of injected therapeutic biomaterials. Clinical translation of this laser surgery technique requires miniaturized high numerical aperture optical systems to treat scarred vocal folds within intact human larynges. The probe presented here provides the small form factors, high pulse energy delivery, and tight beam focusing required for sub-epithelial void formation in scarred vocal folds in vivo. We created large sub-epithelial voids within porcine hemilarynges and injected fluorescently-tagged hydrogels into these voids to demonstrate the probe’s expected performance in vivo. We conclude by discussing integration of the probe into a transportable system as well as future studies to assess clinical viability of this system.

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Citation Download Citation

Liam P. Andrus, Hamin Jeon, Michal Pawlowski, Tomasz Tkaczyk, and Adela Ben-Yakar "Ultrafast laser surgery probe for vocal fold restoration: ablation performance on ex vivo porcine larynges", Proc. SPIE PC11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022, PC1193505 (7 March 2022); https://doi.org/10.1117/12.2608361

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KEYWORDS

Laser therapeutics

Laser ablation

Ultrafast lasers

Surgery

Laser beam diagnostics

Objectives

In vivo imaging

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