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7 March 2022 Lung parenchyma biomechanics in pulmonary fibrosis using endobronchial optical coherence tomography elastography imaging: a preliminary investigation
Arash Dadkhah, Sreyankar Nandy, Sarita Berigei, Ashok Muniappan, Amita Sharma, Melissa J. Suter, Martin Villiger, Corey Hardin, Lida P. Hariri
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Proceedings Volume PC11937, Endoscopic Microscopy XVII; PC119370D (2022) https://doi.org/10.1117/12.2610412
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal type of interstitial lung disease (ILD) characterized by abnormal fibrotic scarring of lung parenchyma. We have demonstrated the use of endobronchial optical coherence tomography (EB-OCT) as a minimally-invasive approach for in vivo diagnosis of ILD in patients with high sensitivity and specificity. Here, we investigate the feasibility of EB-OCT elastography to measure the microscopic mechanical properties of normal and fibrotic lung parenchymal tissue in ex vivo porcine lung and in vivo in human subjects with ILD.
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Arash Dadkhah, Sreyankar Nandy, Sarita Berigei, Ashok Muniappan, Amita Sharma, Melissa J. Suter, Martin Villiger, Corey Hardin, and Lida P. Hariri "Lung parenchyma biomechanics in pulmonary fibrosis using endobronchial optical coherence tomography elastography imaging: a preliminary investigation", Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC119370D (7 March 2022); https://doi.org/10.1117/12.2610412
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KEYWORDS
Lung
Elastography
Coherence imaging
Optical coherence tomography
Pulmonary fibrosis
In vivo imaging
Computed tomography
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