OCT measurement of mechanical properties in human fetal membranes

Kayvan Samimi; Emmanuel Contreras Guzman; May Wu; Lindsey C. Carlson; Helen Feltovich; Timothy J. Hall; Kristin M. Myers; Melissa C. Skala

doi:10.1117/12.2613111

7 March 2022 OCT measurement of mechanical properties in human fetal membranes

Kayvan Samimi, Emmanuel Contreras Guzman, May Wu, Lindsey C. Carlson, Helen Feltovich, Timothy J. Hall, Kristin M. Myers, Melissa C. Skala

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Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC119480P (2022) https://doi.org/10.1117/12.2613111
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Fetal membranes have important mechanical and antimicrobial roles in maintaining pregnancy. However, compared to other pregnancy tissues (e.g., uterus, cervix, placenta), they are understudied. Their low thickness (<800 µm) places them outside the resolution limits of most ultrasound and magnetic resonance scanners. As such, optical imaging methods like OCT have the potential to fill this technical gap. Here, an application of OCT imaging and machine learning for studying (ex vivo) the mechanical properties of the multilayered fetal membranes and correlating them with gestation and birth condition (i.e., labored vs. unlabored), and anatomy (i.e., near vs. far from cervix) is presented.

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Kayvan Samimi, Emmanuel Contreras Guzman, May Wu, Lindsey C. Carlson, Helen Feltovich, Timothy J. Hall, Kristin M. Myers, and Melissa C. Skala "OCT measurement of mechanical properties in human fetal membranes", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC119480P (7 March 2022); https://doi.org/10.1117/12.2613111

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KEYWORDS

Optical coherence tomography

Fetus

Cervix

Light scattering

Multilayers

Scattering

Tissues

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