In-vivo non-contact functional and structural ophthalmic imaging using a dual-modal photoacoustic remote sensing and swept-source optical coherence tomography system

Nima Abbasi Firoozjah; Zohreh Hosseinaee; Nicholas Pellegrino; Layla Khalili; Lyazzat Mukhangaliyeva; Parsin Haji Reza

doi:10.1117/12.2609021

23 March 2022 In-vivo non-contact functional and structural ophthalmic imaging using a dual-modal photoacoustic remote sensing and swept-source optical coherence tomography system

Nima Abbasi Firoozjah, Zohreh Hosseinaee, , Nicholas Pellegrino, Layla Khalili, Lyazzat Mukhangaliyeva, Parsin Haji Reza

Author Affiliations +

Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119600D (2022) https://doi.org/10.1117/12.2609021
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In this work, a synchronized dual-modal imaging system is used for in-vivo, non-contact ophthalmic imaging. The apparatus is comprised of both Photoacoustic Remote Sensing (PARS) and Swept-Source Optical Coherence Tomography (SS-OCT) subsystems. The PARS utilizes a multi-wavelength excitation source to target hemoglobin absorption and an 830 nm interrogation source to detect photoacoustic signals. PARS provides the measurements for computing blood oxygen saturation (sO2) mapping in the mouse and rat eyes. Meanwhile, a 1060 nm SS-OCT is employed to obtain volumetric tissue structure. To our knowledge, this is the first report of non-contact functional photoacoustic imaging in ophthalmic applications.

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Nima Abbasi Firoozjah, Zohreh Hosseinaee, , Nicholas Pellegrino, Layla Khalili, Lyazzat Mukhangaliyeva, and Parsin Haji Reza "In-vivo non-contact functional and structural ophthalmic imaging using a dual-modal photoacoustic remote sensing and swept-source optical coherence tomography system", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119600D (23 March 2022); https://doi.org/10.1117/12.2609021

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