Monitoring electrically-evoked hemodynamic responses in the squirrel monkey brain using photoacoustic computed tomography and photoacoustic microscopy

Kai-Wei Chang; Yunhao Zhu; Heather Hudson; Scott Barbay; David Guggenmos; Randolph J. Nudo; Xinmai Yang; Xueding Wang

doi:10.1117/12.2608287

7 March 2022 Monitoring electrically-evoked hemodynamic responses in the squirrel monkey brain using photoacoustic computed tomography and photoacoustic microscopy

Kai-Wei Chang, Yunhao Zhu, Heather Hudson, Scott Barbay, David Guggenmos, Randolph J. Nudo, Xinmai Yang, Xueding Wang

Author Affiliations +

Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119600B (2022) https://doi.org/10.1117/12.2608287
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The feasibility of using photoacoustic imaging (PAI) to measure electrically-evoked hemodynamic responses in a squirrel monkey brain in vivo was examined. A linear-array photoacoustic computed tomography (PACT) system and a high-resolution photoacoustic microscopy (PAM) system were built for imaging subcortical and cortical brain regions, respectively. The hemodynamic responses at multiple cortices, including premotor, primary motor, and primary somatosensory cortices, were monitored. The variations could be observed in all cortices and their underlying cortical and subcortical brain regions. The results from this study validated the potential of PAI technique for multiscale and multi-resolution functional brain mapping for non-human primates.

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Kai-Wei Chang, Yunhao Zhu, Heather Hudson, Scott Barbay, David Guggenmos, Randolph J. Nudo, Xinmai Yang, and Xueding Wang "Monitoring electrically-evoked hemodynamic responses in the squirrel monkey brain using photoacoustic computed tomography and photoacoustic microscopy", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119600B (7 March 2022); https://doi.org/10.1117/12.2608287

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