Monolayer WSe2 field-effect transistor biosensor for detecting COVID-19 virus (SARS-CoV-2)

Parvin Fathi-Hafshejani; Nurul Azam; Lu Wang; Marcelo Kuroda; Michael Hamilton; Sahar Hasim; Masoud Mahjouri-Samani

doi:10.1117/12.2608310

1 April 2022 Monolayer WSe₂ field-effect transistor biosensor for detecting COVID-19 virus (SARS-CoV-2)

Parvin Fathi-Hafshejani, Nurul Azam, Lu Wang, Marcelo Kuroda, Michael Hamilton, Sahar Hasim, Masoud Mahjouri-Samani

Proceedings Volume PC11990, Nanoscale and Quantum Materials: From Synthesis and Laser Processing to Applications 2022; PC119900L (2022) https://doi.org/10.1117/12.2608310
Event: SPIE LASE, 2022, San Francisco, California, United States

Abstract

In this study, we demonstrate the potential application of 2D monolayer WSe2-based field-effect transistors (2D-FETs) as a promising biosensor for the selective and rapid detection of SARS-CoV-2 in vitro. The sensors are manufactured by first growing the 2D crystals on Si/SiO2 substrates, followed by photolithography processes to form the FET devices. WSe2 crystals are then functionalized with a specific antibody to selectively detect the SARS-CoV-2 spike protein. We demonstrate a detection limit of down to 25 fg/μL in 0.01 PBS. The TMDC-based 2D-FETs can potentially serve as sensitive and selective biosensors for the rapid detection of infectious diseases.

Conference Presentation

Citation Download Citation

Parvin Fathi-Hafshejani, Nurul Azam, Lu Wang, Marcelo Kuroda, Michael Hamilton, Sahar Hasim, and Masoud Mahjouri-Samani "Monolayer WSe₂ field-effect transistor biosensor for detecting COVID-19 virus (SARS-CoV-2)", Proc. SPIE PC11990, Nanoscale and Quantum Materials: From Synthesis and Laser Processing to Applications 2022, PC119900L (1 April 2022); https://doi.org/10.1117/12.2608310

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