Estimating the optical properties of multi-layered tissue models using structured interrogation frequency-domain near-infrared spectroscopy

Ola S. A. Abdalsalam; Thomas D. O'Sullivan; Scott Howard

doi:10.1117/12.2650962

7 March 2023 Estimating the optical properties of multi-layered tissue models using structured interrogation frequency-domain near-infrared spectroscopy

Ola S. A. Abdalsalam, Thomas D. O'Sullivan, Scott Howard

Author Affiliations +

Proceedings Volume PC12376, Optical Tomography and Spectroscopy of Tissue XV; PC1237603 (2023) https://doi.org/10.1117/12.2650962
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Structured interrogation (SI) is a frequency-domain NIRS technique that adjusts the relative phase between intensity-modulated light sources and generates a various spatial pattern of depth sensitivity. It can be used to extract quantitative information from multi-layered tissues. We apply Cramér-Rao lower bound (CRLB) analysis for phase selection. Then, the selected SI phases are used to resolve the optical properties of a fat/muscle tissue model. We found that CRLB is effective for selecting SI phase shift, and a combination of SI measurements and multi-distance measurements can result in an accurate estimation of optical properties and allow for more compact fd-NIRS probes.

Conference Presentation

Citation Download Citation

Ola S. A. Abdalsalam, Thomas D. O'Sullivan, and Scott Howard "Estimating the optical properties of multi-layered tissue models using structured interrogation frequency-domain near-infrared spectroscopy", Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC1237603 (7 March 2023); https://doi.org/10.1117/12.2650962

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