Pulsatile microvascular cerebral blood flow waveforms as a biomarker of vascular health

Tara M. Urner; Kyle Cowdrick; Eashani Sathialingam; Erin M. Buckley

doi:10.1117/12.2650455

7 March 2023 Pulsatile microvascular cerebral blood flow waveforms as a biomarker of vascular health

Tara M. Urner, Kyle Cowdrick, Eashani Sathialingam, Erin M. Buckley

Proceedings Volume PC12376, Optical Tomography and Spectroscopy of Tissue XV; PC123760H (2023) https://doi.org/10.1117/12.2650455
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Interpretation of cardiac pulsatility in cerebral blood flow measured with transcranial doppler ultrasound (TCD) plays an important role in neurocritical care. However, TCD is only sensitive to large arteries, whereas the optical technique diffuse correlation spectroscopy (DCS) can detect microvascular flow. We develop and apply analysis methods to quantify morphological features of cerebral blood flow waveforms measured with DCS. We characterize normative waveforms in healthy adults at rest and report a waveform response to an intervention known to induce vasodilation (hypercapnia). We further show changes in waveform morphology in subarachnoid hemorrhage (SAH) patients with cerebral vasospasm compared to healthy controls.

Conference Presentation

Citation Download Citation

Tara M. Urner, Kyle Cowdrick, Eashani Sathialingam, and Erin M. Buckley "Pulsatile microvascular cerebral blood flow waveforms as a biomarker of vascular health", Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC123760H (7 March 2023); https://doi.org/10.1117/12.2650455

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