Multiscale Imaging of tumor targeted drug delivery (Conference Presentation)

Margarida Barroso

doi:10.1117/12.2649392

15 March 2023 Multiscale Imaging of tumor targeted drug delivery (Conference Presentation)

Margarida Barroso

Proceedings Volume PC12384, Multiphoton Microscopy in the Biomedical Sciences XXIII; PC1238409 (2023) https://doi.org/10.1117/12.2649392
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Macroscopic fluorescence lifetime FRET imaging (MFLI-FRET) presents a much-needed analytical tool to non-invasively quantify drug-receptor engagement in tumors and other organs in preclinical studies. We demonstrate the specificity and sensitivity of MFLI-FRET for direct and robust measurement of trastuzumab-HER2 target engagement in various types of breast and ovarian cancer tumor xenograft models.

Conference Presentation

Citation Download Citation

Margarida Barroso "Multiscale Imaging of tumor targeted drug delivery (Conference Presentation)", Proc. SPIE PC12384, Multiphoton Microscopy in the Biomedical Sciences XXIII, PC1238409 (15 March 2023); https://doi.org/10.1117/12.2649392

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