Optical photothermal infrared spectroscopy and imaging for identification of infections and cancers (Conference Presentation)

Christoph Krafft; Jürgen Popp

doi:10.1117/12.2654900

15 March 2023 Optical photothermal infrared spectroscopy and imaging for identification of infections and cancers (Conference Presentation)

Christoph Krafft, Jürgen Popp

Author Affiliations +

Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; PC123920Q (2023) https://doi.org/10.1117/12.2654900
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Infrared microspectroscopy has been shown to be a powerful tool for biomedical applications, e.g. to assess bacteria, cells and tissues. Quantum cascade laser-based optical photothermal infrared (O-PTIR) spectroscopy and imaging have been introduced which offers submicron spatial resolution, non-contact measurements, and measurement of samples in aqueous media. O-PTIR spectra and single wavenumber images of cells were recorded with subcellular resolution, and the spectral data were used to develop a six-cell classification model for blood cells and their changes related to infections. Tissue sections of a murine model for infection disease have also been studied be O-PTIR spectroscopy and imaging.

Conference Presentation

Citation Download Citation

Christoph Krafft and Jürgen Popp "Optical photothermal infrared spectroscopy and imaging for identification of infections and cancers (Conference Presentation)", Proc. SPIE PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, PC123920Q (15 March 2023); https://doi.org/10.1117/12.2654900

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