Monitoring circulating melanoma cells by in vivo photoacoustic flow cytometry

Xunbin Wei

doi:10.1117/12.3004651

13 March 2024 Monitoring circulating melanoma cells by in vivo photoacoustic flow cytometry

Xunbin Wei

Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC1284308 (2024) https://doi.org/10.1117/12.3004651
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Melanoma is the most serious kind of skin cancer. Circulating melanoma cells, the prognosis marker for metastasis, are present in the circulation at the early stage. Thus, quantitative detection of rare circulating melanoma cells is essential for monitoring tumor metastasis and prognosis evaluation. Compared with in vitro assays, in vivo flow cytometry is able to identify circulating tumor cells without drawing blood. Here, we have built in vivo photoacoustic flow cytometry based on the high absorption coefficient and monitoring circulating melanoma cells, which is useful for evaluating cancer stage and monitoring therapeutic effects.

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Xunbin Wei "Monitoring circulating melanoma cells by in vivo photoacoustic flow cytometry", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC1284308 (13 March 2024); https://doi.org/10.1117/12.3004651

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KEYWORDS

Melanoma

Flow cytometry

Photoacoustic spectroscopy

Tumors

Blood

Cancer

Cancer detection

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