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13 March 2024 Synergistically enhanced cancer phototheranostics using multifunctional nanoplatforms
Tymish Y. Ohulchanskyy
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Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC128430D (2024) https://doi.org/10.1117/12.3008213
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Nanotheranostics combining photodynamic and photothermal therapies (PDT and PTT) with other therapeutic modalities has been shown to result in synergistically enhanced cancer treatment with minimal adverse effects. This talk will present our results on synergistically enhanced cancer phototheranostics delivered with tumor microenvironment or external stimuli responsive multifunctional nanoplatforms. Three different nanoplatforms involve protein nanocrystals, nanoliposomes and silica-based hybrid nanoparticles. All the nanoplatforms incorporate contrast agents for optical/multimodal imaging and therapeutic agents allowing to combine PDT/PTT with chemo and chemodynamic therapies. An application of these imaging guided nanoplatforms allowed us to achieve a synergistic combination of photodynamic and/or photothermal therapies with chemo- and chemodynamic treatments, resulting in an efficient diagnostics and enhanced therapy of cancer cells in vitro and in animal model in vivo.
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Tymish Y. Ohulchanskyy "Synergistically enhanced cancer phototheranostics using multifunctional nanoplatforms", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC128430D (13 March 2024); https://doi.org/10.1117/12.3008213
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KEYWORDS
Cancer
Photodynamic therapy
Therapeutics
Oncology
Tumors
Safety
Silica
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