Characterization Of Oligomeric Hematoporphyrin Tumoricidal Reagents For Photodynamic Therapy

Brian Musselman; Chi K. Chang

doi:10.1117/12.942695

19 February 1988 Characterization Of Oligomeric Hematoporphyrin Tumoricidal Reagents For Photodynamic Therapy

Brian Musselman, Chi K. Chang

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942695
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

The primary structure of the tumor-localizing component of Hematoporphyrin Derivative (HPD) has been shown by fast atom bombardment (FAB) mass spectrometry to consist of hematoporphyrin (HP)-based oligomers of up to five subunits with a general formula of nHP-(n-1)H2O. The nature of the covalent bond linking the porphyrin units has been probed by LiA1H4-reduction and by diazomethane-permethylation of the oligomer-containing fraction of the drug. Results suggest that both ether and ester groups are present and that the composition may be dependent on the shelf-life and the preparative method employed. Cell assay with HPD preparations enriched in ether or ester content indicates that variations of the linkage between porphyrin units have essentially no effect on the photodynamic activity.

Citation Download Citation

Brian Musselman and Chi K. Chang "Characterization Of Oligomeric Hematoporphyrin Tumoricidal Reagents For Photodynamic Therapy", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942695

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