Potential Use Of Mitochondria As A Reservoir For Photosensitive Lipophilic Cations

Lan Bo Chen

doi:10.1117/12.942688

19 February 1988 Potential Use Of Mitochondria As A Reservoir For Photosensitive Lipophilic Cations

Lan Bo Chen

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942688
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

Fluorescent lipophilic cations such as rhodamine 123 have been used to localize mitochondria in living cells. The specific uptake is resulted from the uniquely high membrane potential across mitochondria. Although mitochondria in all cells take up rhodamine 123, the degrees of uptake and retention vary from one cell type to the other. Many carcinoma cell types/lines have a higher uptake and longer retention of rhodamine 123 than that of normal epithelial cells, probably resulted from higher mitochondrial and plasma membrane potentials. This phenotype has been exploited for selective killing of carcinoma cells in vitro as well as in vivo. Mitochondria may be used as a reservoir and a slow-releasing device for photosensitive, lipophilic, cationic drugs.

Citation Download Citation

Lan Bo Chen "Potential Use Of Mitochondria As A Reservoir For Photosensitive Lipophilic Cations", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942688

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available