Quantifying time-of-flight-resolved optical field dynamics in turbid media with interferometric near-infrared spectroscopy (iNIRS) (Conference Presentation)

Dawid Borycki; Oybek Kholiqov; Wenjun Zhou; Vivek J. Srinivasan

doi:10.1117/12.2252654

19 April 2017 Quantifying time-of-flight-resolved optical field dynamics in turbid media with interferometric near-infrared spectroscopy (iNIRS) (Conference Presentation)

Dawid Borycki, Oybek Kholiqov, Wenjun Zhou, Vivek J. Srinivasan

Author Affiliations +

Proceedings Volume 10063, Dynamics and Fluctuations in Biomedical Photonics XIV; 100630P (2017) https://doi.org/10.1117/12.2252654
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Sensing and imaging methods based on the dynamic scattering of coherent light, including laser speckle, laser Doppler, and diffuse correlation spectroscopy quantify scatterer motion using light intensity (speckle) fluctuations. The underlying optical field autocorrelation (OFA), rather than being measured directly, is typically inferred from the intensity autocorrelation (IA) through the Siegert relationship, by assuming that the scattered field obeys Gaussian statistics. In this work, we demonstrate interferometric near-infrared spectroscopy (iNIRS) for measurement of time-of-flight (TOF) resolved field and intensity autocorrelations in fluid tissue phantoms and in vivo. In phantoms, we find a breakdown of the Siegert relationship for short times-of-flight due to a contribution from static paths whose optical field does not decorrelate over experimental time scales, and demonstrate that eliminating such paths by polarization gating restores the validity of the Siegert relationship. Inspired by these results, we developed a method, called correlation gating, for separating the OFA into static and dynamic components. Correlation gating enables more precise quantification of tissue dynamics. To prove this, we show that iNIRS and correlation gating can be applied to measure cerebral hemodynamics of the nude mouse in vivo using dynamically scattered (ergodic) paths and not static (non-ergodic) paths, which may not be impacted by blood. More generally, correlation gating, in conjunction with TOF resolution, enables more precise separation of diffuse and non-diffusive contributions to OFA than is possible with TOF resolution alone. Finally, we show that direct measurements of OFA are statistically more efficient than indirect measurements based on IA.

Conference Presentation

Citation Download Citation

Dawid Borycki, Oybek Kholiqov, Wenjun Zhou, and Vivek J. Srinivasan "Quantifying time-of-flight-resolved optical field dynamics in turbid media with interferometric near-infrared spectroscopy (iNIRS) (Conference Presentation)", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100630P (19 April 2017); https://doi.org/10.1117/12.2252654

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KEYWORDS

Near infrared spectroscopy

Dynamic light scattering

Interferometry

Laser scattering

Light scattering

In vivo imaging

Speckle

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