Basic mechanisms and subcellular targets related to PDT

Charles J. Gomer

doi:10.1117/12.2283673

21 January 1990 Basic mechanisms and subcellular targets related to PDT

Charles J. Gomer

Proceedings Volume 10306, Future Directions and Applications in Photodynamic Therapy; 103060B (1990) https://doi.org/10.1117/12.2283673
Event: SPIE Institutes for Advanced Optical Technologies 6, 1990, San Diego, California, United States

Abstract

The continued examination of injury sites and mechanisms of cytotoxicity associated with photodynamic therapy (PDT) can take advantage of current molecular and/or biochemical techniques. The increased expression of oxidative stress proteins can be studied as a function of photosensitizer type, treatment conditions and cell type. However, while in-vitro studies can address questions regarding subcellular PDT targets there is growing evidence that in-vivo effects of PDT are mediated by both vascular and direct tumor cell injury. Preclinical PDT studies using mono-l-aspartyl chlorin e6 (NPe6) confirm that the efficacy of this photosensitizer is correlated with plasma levels of this compound and not tumor cell levels.

Citation Download Citation

Charles J. Gomer "Basic mechanisms and subcellular targets related to PDT", Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060B (21 January 1990); https://doi.org/10.1117/12.2283673

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