DNA scaffold nanostructures for efficient and directional propagation of light harvesting cascades

Carl W. Brown III; Anirban Samanta; Susan Buckhout-White; Sebastián A. Díaz; Scott A. Walper; Ellen R. Goldman; Igor L. Medintz

doi:10.1117/12.2274639

29 August 2017 DNA scaffold nanostructures for efficient and directional propagation of light harvesting cascades

Carl W. Brown III, Anirban Samanta, Susan Buckhout-White, Sebastián A. Díaz, Scott A. Walper, Ellen R. Goldman, Igor L. Medintz

Author Affiliations +

Proceedings Volume 10355, Nanobiosystems: Processing, Characterization, and Applications X; 1035503 (2017) https://doi.org/10.1117/12.2274639
Event: SPIE Nanoscience + Engineering, 2017, San Diego, California, United States

Abstract

The development of light harvesting systems for directed, efficient control of energy transfer at the biomolecular level has generated considerable interest in the past decade. Molecular fluorophores provide a straightforward mechanism for determining nanoscale distance changes through Förster resonance energy transfer (FRET), and many systems seek to build off of this simple yet powerful principle to provide additional functionality. The use of DNA-based integrated biomolecular devices offer many unique advantages towards this end. DNA itself is an excellent engineering material – it is innately biocompatible, quickly and cheaply synthesized, and complex structures can be readily designed in silico. It also provides an excellent scaffold for the precise patterning of various biomolecules. Here, we discuss the systems that have been recently developed which add to this toolbox, including nanostructural dye patterning, photonic wires, and the incorporation of alternative energy propagation modalities, such as semiconductor quantum dots (QD) and the bioluminescent protein luciferase. In particular, we explore the incorporation of luciferase into various nanostructural conformations, providing the capability to efficiently control energy flow directionality. We discuss the nature of this system, including unexpected spectral complexities, in the context of the field.

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Carl W. Brown III, Anirban Samanta, Susan Buckhout-White, Sebastián A. Díaz, Scott A. Walper, Ellen R. Goldman, and Igor L. Medintz "DNA scaffold nanostructures for efficient and directional propagation of light harvesting cascades", Proc. SPIE 10355, Nanobiosystems: Processing, Characterization, and Applications X, 1035503 (29 August 2017); https://doi.org/10.1117/12.2274639

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