Catheter design optimization for practical intravascular photoacoustic imaging (IVPA) of vulnerable plaques

Sophinese Iskander-Rizk; Min Wu; Geert Springeling; Frits Mastik; Robert H. S. H. Beurskens; Antonius F. W. van der Steen; Gijs van Soest

doi:10.1117/12.2287364

14 February 2018 Catheter design optimization for practical intravascular photoacoustic imaging (IVPA) of vulnerable plaques

Sophinese Iskander-Rizk, Min Wu, Geert Springeling, Frits Mastik, Robert H. S. H. Beurskens, Antonius F. W. van der Steen, Gijs van Soest

Author Affiliations +

Proceedings Volume 10471, Diagnostic and Therapeutic Applications of Light in Cardiology 2018; 1047111 (2018) https://doi.org/10.1117/12.2287364
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Intravascular photoacoustic/ultrasound imaging (IVPA/US) can image the structure and composition of atherosclerotic lesions identifying lipid-rich plaques ex vivo and in vivo. In the literature, multiple IVPA/US catheter designs were presented and validated both in ex-vivo models and preclinical in-vivo situations. Since the catheter is a critical component of the imaging system, we discuss here a catheter design oriented to imaging plaque in a realistic and translatable setting. We present a catheter optimized for light delivery, manageable flush parameters and robustness with reduced mechanical damage risks at the laser/catheter joint interface. We also show capability of imaging within sheath and in water medium.

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Sophinese Iskander-Rizk, Min Wu, Geert Springeling, Frits Mastik, Robert H. S. H. Beurskens, Antonius F. W. van der Steen, and Gijs van Soest "Catheter design optimization for practical intravascular photoacoustic imaging (IVPA) of vulnerable plaques", Proc. SPIE 10471, Diagnostic and Therapeutic Applications of Light in Cardiology 2018, 1047111 (14 February 2018); https://doi.org/10.1117/12.2287364

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