Nanoprobes for optical fluorescence imaging (Conference Presentation)

Hak Soo Choi

doi:10.1117/12.2287971

14 March 2018 Nanoprobes for optical fluorescence imaging (Conference Presentation)

Hak Soo Choi

Proceedings Volume 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV; 104780G (2018) https://doi.org/10.1117/12.2287971
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Two fundamental and unsolved problems facing bioimaging and nanomedicine are nonspecific uptake of intravenously administered diagnostic and/or therapeutic agents by normal tissues and organs, and incomplete elimination of unbound targeted agents from the body. To solve these problems, we have synthesized a series of indocyanine near-infrared (NIR) fluorophores that varied systematically in net charge, conformational shape, hydrophilicity/lipophilicity, and charge distribution. Using 3D molecular modeling and optical fluorescence imaging, we have defined the relationship among the key independent variables that dictate biodistribution and tissue-specific targeting such as lung and sentinel lymph nodes (Nat Biotechnol. 2010), human prostate cancers (Nat Nanotechnol. 2010), and human melanomas (Nat Biotechnol. 2013). Recently, we have developed new pharmacophore design strategy “structure-inherent targeting,” where tissue- and/or organ-specific targeting is engineered directly into the non-resonant structure of a NIR fluorophore, thus creating the most compact possible optical contrast agent for bioimaging and nanomedicine (Angew Chem. 2015, Nat Med. 2015). The biodistribution and targeting of these compounds vary with dependence on their unique physicochemical descriptors and cellular receptors, which permit 1) selective binding to the target tissue/organ, 2) visualization of the target specifically and selectively, and 3) provide curing options such as image-guided surgery or photo dynamic therapy. Our study solves two fundamental problems associated with fluorescence image-guided surgery and lays the foundation for additional targeted agents with optimal optical and in vivo performance.

Conference Presentation

Citation Download Citation

Hak Soo Choi "Nanoprobes for optical fluorescence imaging (Conference Presentation)", Proc. SPIE 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV, 104780G (14 March 2018); https://doi.org/10.1117/12.2287971

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Tissue optics

Image-guided intervention

Luminescence

Optical imaging

3D modeling

Diagnostics

Nanomedicine

Show All Keywords

Keywords/Phrases

Search In:

Publication Years