Structural characterization on in vitro porcine skin treated by ablative fractional laser using optical coherence tomography

Kairui Feng; Kanheng Zhou; Yuting Ling; Paul O'Mahoney; Eadie Ewan; Sally H. Ibbotson; Chunhui Li; Zhihong Huang

doi:10.1117/12.2288492

19 February 2018 Structural characterization on in vitro porcine skin treated by ablative fractional laser using optical coherence tomography

Kairui Feng, Kanheng Zhou, Yuting Ling, Paul O'Mahoney, Eadie Ewan, Sally H. Ibbotson, Chunhui Li, Zhihong Huang

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Proceedings Volume 10496, Optical Elastography and Tissue Biomechanics V; 104960H (2018) https://doi.org/10.1117/12.2288492
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Ablative fractional skin laser is widely applied for various skin conditions, especially for cosmetic repairing and promoting the located drug delivery. Although the influence of laser treatment over the skin has been explored before in means of excision and biopsy with microscopy, these approaches are invasive, only morphological and capable of distorting the skin. In this paper the authors use fresh porcine skin samples irradiated by the lasers, followed by detected by using Optical Coherence Tomography (OCT). This advanced optical technique has the ability to present the high resolution structure image of treated sample. The results shows that laser beams can produce holes left on the surface after the irradiation. The depth of holes can be affected by changes of laser energy while the diameter of holes have no corresponding relation. Plus, OCT, as a valuable imaging technology, is capable of monitoring the clinical therapy procedure and assisting the calibration.

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Kairui Feng, Kanheng Zhou, Yuting Ling, Paul O'Mahoney, Eadie Ewan, Sally H. Ibbotson, Chunhui Li, and Zhihong Huang "Structural characterization on in vitro porcine skin treated by ablative fractional laser using optical coherence tomography", Proc. SPIE 10496, Optical Elastography and Tissue Biomechanics V, 104960H (19 February 2018); https://doi.org/10.1117/12.2288492

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