Toxicological evaluation of Cd-based fluorescent nanoprobes by means of in vivo studies

Patricia M. A. Farias; Lan Ma-Hock; Robert Landsiedel; Bennard van Ravenzwaay

doi:10.1117/12.2289341

20 February 2018 Toxicological evaluation of Cd-based fluorescent nanoprobes by means of in vivo studies

Patricia M. A. Farias, Lan Ma-Hock, Robert Landsiedel, Bennard van Ravenzwaay

Proceedings Volume 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X; 105080H (2018) https://doi.org/10.1117/12.2289341
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Cadmium still represents a stigma for many research- and/or industrial applications. Some deleterious effects are attributed to Cadmium. In the present work, highly fluorescent Cadmium sulfide quantum dots are investigated by e.g. physical-chemical characterization. Most important however is their application as fluorescent probes for bio-imaging in living cells and tissues. This work presents their toxicological evaluation by means of in vivo studies. Bio-imaging experiments are performed without any pre-treatment. The toxicological studies performed, strongly indicate that the use of Cadmium based nanoparticles as fluorescent probes may be nonhazardous and not induce side effects for cells/tissues.

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Citation Download Citation

Patricia M. A. Farias, Lan Ma-Hock, Robert Landsiedel, and Bennard van Ravenzwaay "Toxicological evaluation of Cd-based fluorescent nanoprobes by means of in vivo studies", Proc. SPIE 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X, 105080H (20 February 2018); https://doi.org/10.1117/12.2289341

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