Terahertz spectroscopy using an injection-seeded terahertz parametric generator for quantitative analysis and inspection of over-the-counter medicine tablets

M. Mohara; K. Shimura; K. Aiko; K. Kawase

doi:10.1117/12.2288029

23 February 2018 Terahertz spectroscopy using an injection-seeded terahertz parametric generator for quantitative analysis and inspection of over-the-counter medicine tablets

M. Mohara, K. Shimura, K. Aiko, K. Kawase

Author Affiliations +

Proceedings Volume 10531, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XI; 1053121 (2018) https://doi.org/10.1117/12.2288029
Event: SPIE OPTO, 2018, San Francisco, California, United States

Abstract

The pharmaceutical industry requires a simple nondestructive quantitative inspection technique that does not change the characteristic properties of the target of inspection. Terahertz (THz) spectroscopy has potential as a nondestructive inspection technique because of the high transmittance of inspected materials and the absorption peaks related to some active pharmaceutical ingredients (APIs) in THz frequency regions. We have developed a compact terahertz spectroscopy system that uses an injection-seeded terahertz parametric generator (is-TPG) as a THz light source for the inspection and quantitative analysis of pharmaceutical tablets. Using this system, acetylsalicylic acid, acetaminophen, tranexamic acid, loxoprofen sodium, and caffeine included in over-the-counter (OTC) medicine tablets were identified as APIs by their specific absorption peaks. We also conducted a quantitative analysis of acetaminophen in one of the medicines by performing multivariate analyses. The root-mean-squared error of cross-validation (RMSECV) was 0.297 wt%. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.990 wt% and 3.00 wt%, respectively. These results indicate that this is-TPG system could be applied as an inspection and quantitative analysis technique for OTC medicine tablets.

Citation Download Citation

M. Mohara, K. Shimura, K. Aiko, and K. Kawase "Terahertz spectroscopy using an injection-seeded terahertz parametric generator for quantitative analysis and inspection of over-the-counter medicine tablets", Proc. SPIE 10531, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XI, 1053121 (23 February 2018); https://doi.org/10.1117/12.2288029

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KEYWORDS

Tablets

Terahertz radiation

Absorption

Inspection

Medicine

Quantitative analysis

Terahertz spectroscopy

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