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Its use in auto catalysts results in environmental contamination of crowded cities and high-traffic roads. In medicine, Pt is used as a cytostatic drug. Specific platinum complexes, especially cis-diamminedichloroplatinum (II) (cisplatin), Cis-[oxalate (trans-1-1,2- diaminocyclohexane)] platinum(II) (oxaliplatin) and cis-diammine (1,1- cyclobutanedicarboxylato) platinum(II) (carboplatin), used in therapeutic practice [1,2]. Determination of the Pt concentration in biological samples provides medical personnel with useful information on the efficacy of the cytostatic treatment. An optoelectronic method for determining the concentration of Pt in urine, blood and hair samples collected from patients undergoing cytostatic treatment with platinum-based products is presented. To determine the concentration of Pt in biological products was used: Atomic Absorption Spectrometer model AAS-880, Atomization in the graphite furnace model GT 100, Programable Sample Dispenser PSD - Varian. Platinum concentrations of biological samples collected from platinum, based cytotoxic patients are presented. The presented method can be used to monitor platinumbased chemotherapy with platinum compounds. Graphite Furnace Atomic Absorption Spectroscopy (GF-AAS) method presented is sensitive, reproducible, and relatively easy to apply with an acceptable cost. |
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Platinum
Blood
Calibration
Spectroscopy
Absorption
Optoelectronics
Absorbance
