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7 August 2019 The role of proteoglycan genes in PDT-resistant HEp-2 cells
Cristina Pacheco-Soares, Roberta Kelly de Faria Souza, Isabel Chaves Silva Carvalho, Renata A. Canevari, Bruno Henrique Godoi, Carlos Dailton G. O. Moraes, Ritchelli Ricci, Juliana Ferreira Strixino
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Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 11070AF (2019) https://doi.org/10.1117/12.2528183
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States
Abstract
Optimizing the parameters of PDT for specific cancer cells by identifying the mechanisms involved in the process represents a considerable tool for the development of photosensitizer delivery systems and the improvement of PDT targets for cancer. Proteoglycans, important constituents of extracellular matrix (ECM) play an important role in both progression and inhibition of tumor development. This study determines by gene expression whether proteoglycan are associated with PDT resistance observed in human epidermoid larynx carcinoma cells (HEp-2). We conclude that PDT increases the expression of DECORIN and BIGLYCAN genes, involved in metastatic dissemination, leading to inhibitory effect growth in Hep-2 cells
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Cristina Pacheco-Soares, Roberta Kelly de Faria Souza, Isabel Chaves Silva Carvalho, Renata A. Canevari, Bruno Henrique Godoi, Carlos Dailton G. O. Moraes, Ritchelli Ricci, and Juliana Ferreira Strixino "The role of proteoglycan genes in PDT-resistant HEp-2 cells", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070AF (7 August 2019); https://doi.org/10.1117/12.2528183
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KEYWORDS
Photodynamic therapy
Cancer
Resistance
Tumors
Oncology
Photosensitizer targeting
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