Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics

Alexey Lihachev; Emilija Vija Plorina; Marta Lange; Ilze Lihacova; Alexander Derjabo; Dmitrijs Bliznuks

doi:10.1117/12.2526260

19 July 2019 Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics

Alexey Lihachev, Emilija Vija Plorina, Marta Lange, Ilze Lihacova, Alexander Derjabo, Dmitrijs Bliznuks

Proceedings Volume 11073, Clinical and Preclinical Optical Diagnostics II; 110731S (2019) https://doi.org/10.1117/12.2526260
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

The aim of this study is to develop a novel non-invasive approach for skin cancer (melanoma, basal cell and squamous cell carcinomas) diagnostics by mapping the AF intensity decrease (photo-bleaching) rates under continuous 405 nm LED excitation. For parametric mapping of skin AF intensity decrease rates a sequence of filtered AF imaging under 405 nm LED excitation for 20 seconds at a power density of ~7 mW/cm² with a frame rate 0.5 fps was recorded and analyzed by cloud-based prototype device. Several clinical cases and potential future applications of the proposed autofluorescence photobleaching rate imaging technique are discussed.

Citation Download Citation

Alexey Lihachev, Emilija Vija Plorina, Marta Lange, Ilze Lihacova, Alexander Derjabo, and Dmitrijs Bliznuks "Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics", Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 110731S (19 July 2019); https://doi.org/10.1117/12.2526260

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