Time-Resolved multi-wavelength, dual-channel system for diffuse optical spectroscopy: performance assessment

Marta Zanoletti; Marco Renna; Mauro Buttafava; Anurag Behera; Pranav Lanka; Laura Di Sieno; Alberto Dalla Mora; Alberto Tosi; Davide Contini

doi:10.1117/12.2527049

11 July 2019 Time-Resolved multi-wavelength, dual-channel system for diffuse optical spectroscopy: performance assessment

Marta Zanoletti, Marco Renna, Mauro Buttafava, Anurag Behera, Pranav Lanka, Laura Di Sieno, Alberto Dalla Mora, Alberto Tosi, Davide Contini

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110742Q (2019) https://doi.org/10.1117/12.2527049
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

In this paper we present the ex-vivo characterization of a full-custom made multi-wavelength, two channel Time-Resolved Spectroscopy (TRS) module developed with the aim of being integrated in to a multi-modal spectroscopic device. This module overcomes all the main drawbacks of systems based on time-domain techniques such as high complexity and bulkiness while guaranteeing performances comparable to expensive state-of-the-art available devices. Each subcomponent of the module has been tailored and optimized to meet all the above-mentioned requirements. In order to assess and translate the performances of these tools for effective clinical use, we characterized the system following the guidelines of common standardization protocols. By following MEDPHOT guidelines, the linearity and accuracy in retrieving absolute values of absorption and scattering coefficients were determined by means of measurements on homogeneous phantoms. Finally, by means of a mechanically switchable solid inhomogeneous phantom (developed under the nEUROPT project) we simulated the clinical problem of detecting and localizing an absorption perturbation in a homogeneous background with broad applications such as detection of cancer lesions, thyroid, etc.

Citation Download Citation

Marta Zanoletti, Marco Renna, Mauro Buttafava, Anurag Behera, Pranav Lanka, Laura Di Sieno, Alberto Dalla Mora, Alberto Tosi, and Davide Contini "Time-Resolved multi-wavelength, dual-channel system for diffuse optical spectroscopy: performance assessment", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110742Q (11 July 2019); https://doi.org/10.1117/12.2527049

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available