Effect of hepatic vein on gold nanoparticle-mediated-hyperthermia in liver cancer

Mandana Jalali; Paul Mertin; Andreas Rennings; Daniel Erni

doi:10.1117/12.2526978

3 October 2019 Effect of hepatic vein on gold nanoparticle-mediated-hyperthermia in liver cancer

Mandana Jalali, Paul Mertin, Andreas Rennings, Daniel Erni

Proceedings Volume 11207, Fourth International Conference on Applications of Optics and Photonics; 112070M (2019) https://doi.org/10.1117/12.2526978
Event: IV International Conference on Applications of Optics and Photonics (AOP 2019), 2019, Lisbon, Portugal

Abstract

Gold nanoparticle-mediated hyperthermia is a non-invasive, target-based cancer treatment with significantly reduced side effects compared to conventional treatments. In this work a simulation model for gold nanoparticlemediated hyperthermia is set up and used to investigate the case of a liver tumor located in the vicinity of a hepatic vein. Gold nanorods with optimized size and aspect ratio are embedded within the liver, and the temperature raise under CW laser illumination is calculated, while taking into account the convective heat transfer through blood perfusion. For this purpose, an analytical model based on the Navier-Stokes equation is used. Results show that due to the heat drain in the blood stream, an effective temperature raise is not achievable when the tumor is located in the vicinity of the hepatic vein. Additionally it is shown that even in the case of a 90% occluded vein, the temperature raise with such nanoparticle arrangement is still not enough for tumor ablation.

Citation Download Citation

Mandana Jalali, Paul Mertin, Andreas Rennings, and Daniel Erni "Effect of hepatic vein on gold nanoparticle-mediated-hyperthermia in liver cancer", Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, 112070M (3 October 2019); https://doi.org/10.1117/12.2526978

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available