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10 March 2020 Biphasic response of LED photobiomodulation measured in vivo on human forearms with near-infrared spectroscopy (Conference Presentation)
Ben Mattison, Paul Mathews, Peter Brawn
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Proceedings Volume 11221, Mechanisms of Photobiomodulation Therapy XV; 112210J (2020) https://doi.org/10.1117/12.2545181
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Photobiomodulation (PBM) treatment using light-emitting diodes (LEDs) has become an attractive alternative to using lasers in recent years. Two arrays of 54 LEDs at 850 nm were used to apply PBM at three different irradiances for 5 minutes to the forearms of 11 human subjects in a placebo-controlled experiment. Near-infrared spectroscopy was used in vivo to track changes in hemoglobin and mitochondrial markers over the course of the treatments. A non-linear biphasic response in these markers was observed with respect to irradiance and time, which suggests that there is an optimal dosimetry for PBM treatment as theorized by the Arndt-Schultz Law.
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Ben Mattison, Paul Mathews, and Peter Brawn "Biphasic response of LED photobiomodulation measured in vivo on human forearms with near-infrared spectroscopy (Conference Presentation)", Proc. SPIE 11221, Mechanisms of Photobiomodulation Therapy XV, 112210J (10 March 2020); https://doi.org/10.1117/12.2545181
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KEYWORDS
Light emitting diodes
Near infrared spectroscopy
In vivo imaging
Human subjects
Semiconductor lasers
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