Fiber optic biosensor based on polydimethylsiloxane (PDMS) and bioactive lipids

Mildred S. Cano-Velázquez; Luz M. López-Marín; Juan Hernández-Cordero

doi:10.1117/12.2546685

20 February 2020 Fiber optic biosensor based on polydimethylsiloxane (PDMS) and bioactive lipids

Mildred S. Cano-Velázquez, Luz M. López-Marín, Juan Hernández-Cordero

Proceedings Volume 11233, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX; 112330Y (2020) https://doi.org/10.1117/12.2546685
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In this work, we demonstrate an optical fiber biosensor based on Fabry-Perot (F-P) interferometers using polydimethylsiloxane (PDMS) as a support for bioactive lipids. The sensors are fabricated by dip-coating producing PDMS end-capped devices. For biosensing, the PDMS cap was functionalized with a previously characterized bioactive lipid antigen cocktail from Mycobacterium fortuitum, used as a surrogate source of antigens for tuberculosis diagnosis. The performance of the biosensor was evaluated upon monitoring the changes in the interference pattern associated to the interactions between the active lipids and the antibody-containing sera. Our results show that the proposed biosensor offers new and attractive possibilities for developing novel lipidomic analytical tools.

Conference Presentation

Citation Download Citation

Mildred S. Cano-Velázquez, Luz M. López-Marín, and Juan Hernández-Cordero "Fiber optic biosensor based on polydimethylsiloxane (PDMS) and bioactive lipids", Proc. SPIE 11233, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX, 112330Y (20 February 2020); https://doi.org/10.1117/12.2546685

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