Semi-supervised learned sinogram restoration network for low-dose CT image reconstruction

Mingqiang Meng; Sui Li; Lisha Yao; Danyang Li; Manman Zhu; Qi Gao; Qi Xie; Qian Zhao; Zhaoying Bian; Jing Huang; Deyu Meng; Dong Zeng; Jianhua Ma Sr.

doi:10.1117/12.2548985

16 March 2020 Semi-supervised learned sinogram restoration network for low-dose CT image reconstruction

Mingqiang Meng, Sui Li, Lisha Yao, Danyang Li, Manman Zhu, Qi Gao, Qi Xie, Qian Zhao, Zhaoying Bian, Jing Huang, Deyu Meng, Dong Zeng, Jianhua Ma Sr.

Author Affiliations +

Proceedings Volume 11312, Medical Imaging 2020: Physics of Medical Imaging; 113120B (2020) https://doi.org/10.1117/12.2548985
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

With the development of deep learning (DL), many deep learning (DL) based algorithms have been widely used in the low-dose CT imaging and achieved promising reconstruction performance. However, most DL-based algorithms need to pre-collect a large set of image pairs (low-dose/high-dose image pairs) and trains networks in a supervised end-to-end manner. Actually, it is not feasible in clinical to obtain such a large amount of paired training data, especially for high-dose ones. Therefore, in this work, we present a semi-supervised learned sinogram restoration network (SLSR-Net) for low-dose CT image reconstruction. The presented SLSR-Net consists of supervised sub-network and unsupervised sub-network. Specifically, different from the traditional supervised DL networks which only use low-dose/high-dose sinogram pairs, the presented SLSR-Net method is capable of feeding only a few supervised sinogram pairs and massive unsupervised low-dose sinograms into the network training procedure. The supervised pairs are used to capture critical features (i.e., noise distribution, and tissue characteristics) latent in a supervised way and the unsupervised sub-network efficiently learns these features using a conventional weighted least-squares model with a regularization term. Moreover, another contribution of the presented SLSR-Net method is to adaptively transfer learned feature distribution from supervised subnetwork with the paired sinograms to unsupervised sub-network with unlabeled low-dose sinograms to obtain high-fidelity sinogram with a Kullback-Leibler divergence. Finally, the filtered backprojection algorithm is used to reconstruct CT images from the obtained sinograms. Real patient datasets are used to evaluate the performance of the presented SLSR-Net method and the corresponding experimental results show that compared with the traditional supervised learning method, the presented SLSR-Net method achieves competitive performance in terms of noise reduction and structure preservation in low-dose CT imaging.

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Mingqiang Meng, Sui Li, Lisha Yao, Danyang Li, Manman Zhu, Qi Gao, Qi Xie, Qian Zhao, Zhaoying Bian, Jing Huang, Deyu Meng, Dong Zeng, and Jianhua Ma Sr. "Semi-supervised learned sinogram restoration network for low-dose CT image reconstruction", Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113120B (16 March 2020); https://doi.org/10.1117/12.2548985

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