The role of NCX in initiation and expansion of astroglial Ca2+ events in a distributed model

Andrey Yu. Verisokin; Darya V. Verveyko; Dmitry E. Postnov; Alexey R. Brazhe

doi:10.1117/12.2564437

9 April 2020 The role of NCX in initiation and expansion of astroglial Ca²⁺ events in a distributed model

Andrey Yu. Verisokin, Darya V. Verveyko, Dmitry E. Postnov, Alexey R. Brazhe

Proceedings Volume 11459, Saratov Fall Meeting 2019: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 114590N (2020) https://doi.org/10.1117/12.2564437
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

We present a two-dimensional model of astrocytic Ca²⁺ dynamics. We take into account two main factors of the considered process: the IP_3-mediated release from intracellular Ca²⁺ stores and the plasma membrane bidirectional exchange, i.e. the Na⁺/Ca²⁺-exchanger (NCX). We based on the Hodgkin - Huxley formalism to describe NCX effects and takes into account the glutamate transporter-mediated increase in Na⁺ during synaptic activity and Na⁺- and Ca²⁺-dependent regulation. The results of the unified model numerical solution confirm the emergence of calcium waves, which occur due to the synaptic activity and spread over the astrocyte network. The presence of NCX leads to a decrease in the average areas that are affected by a global calcium wave during excitation. However, the Na/Ca exchanger stimulates calcium waves, making possible the formation of more long-lived waves.

Citation Download Citation

Andrey Yu. Verisokin, Darya V. Verveyko, Dmitry E. Postnov, and Alexey R. Brazhe "The role of NCX in initiation and expansion of astroglial Ca²⁺ events in a distributed model", Proc. SPIE 11459, Saratov Fall Meeting 2019: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 114590N (9 April 2020); https://doi.org/10.1117/12.2564437

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