Optical spectroscopy to monitor tumor response to immunotherapy

Joel Rodriguez Troncoso; Paola Monterroso Diaz; David E. Lee; Narasimhan Rajaram

doi:10.1117/12.2577873

5 March 2021 Optical spectroscopy to monitor tumor response to immunotherapy

Joel Rodriguez Troncoso, Paola Monterroso Diaz, David E. Lee, Narasimhan Rajaram

Proceedings Volume 11622, Multiscale Imaging and Spectroscopy II; 1162209 (2021) https://doi.org/10.1117/12.2577873
Event: SPIE BiOS, 2021, Online Only

Abstract

We used Diffuse Reflectance spectroscopy (DRS) to investigate functional changes within the tumor microenvironment when treated with different immunotherapy drugs. We injected the CT26 cell line into the flank of 35 mice that were assigned to 4 different groups: anti-PD-1, anti-CTLA-4, combination treatment, and IgG. The 4 groups were injected intraperitoneally on days 1, 4 and 7 (Day 1 – tumor at 80-120 mm3). DRS spectra were acquired simultaneously for 9 consecutive days and a lookup table (LUT)-based inverse model was implemented to decompose the spectral data. We found statistically significant differences in functional changes among the different immunotherapy groups.

Conference Presentation

Citation Download Citation

Joel Rodriguez Troncoso, Paola Monterroso Diaz, David E. Lee, and Narasimhan Rajaram "Optical spectroscopy to monitor tumor response to immunotherapy", Proc. SPIE 11622, Multiscale Imaging and Spectroscopy II, 1162209 (5 March 2021); https://doi.org/10.1117/12.2577873

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available