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Fibromyalgia is characterized by generalized chronic pain with many non-pharmacological therapies available for its treatment. Assessment of quality of life (QoL) for the evaluation of chronic painful patients is a key point of integral treatment. However, the relationship between fibromyalgia, Laser Therapies, and QoL is not known. Aims: to evaluate the current literature regarding the effect of LT in the quality of life of fibromyalgia patients. Methods: in 2020 a systematic review was performed according to the Preferred Reporting Items for Systematic Reviews (PRISMA) statement searching for RCTs in humans following the P.I.C.O. strategy (P=fibromyalgia, I=Laser Therapies C=control group, O= quality of life) at PubMed, EMBASE, LILACS, PeDro and Open Gray database. The quality assessment of studies was analyzed by NIH Quality Assessment Criteria and Cochrane Review Criteria. Results: a total of 822 papers were first identified but only 8 RCT were selected to results including 414 patients. The LLLT as evaluated by FIQ or SF-36 demonstrating significant difference compared with the control group for 03 studies (p = 0.01). Conclusion : So far, only 8 studies have evaluated the quality of life of patients with fibromyalgia after using LT in spite of Qol is the best outcome for chronic pain studies. The 3 studies that found positive results are the studies with the best scientific methodology with placebo controlled groups and a larger sample size, which suggests that the use of laser can be promising in improving the quality of life of fibromyalgia patients.
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