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5 March 2021 Intraoperative FLIm for pathology detection and surgical guidance in oral and oropharyngeal cancer patients
Brent W. Weyers, Mark Marsden, Julien Bec, Takanori Fukazawa, Roberto P. Frusciante, Athena K. Tam, Dorina Gui, Andrew C. Birkeland, Marianne Abouyared, Arnaud F. Bewley, Regina F. Gandour-Edwards, John E. Hanks, D. Gregory Farwell, Laura Marcu
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Proceedings Volume 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX; 116310V (2021) https://doi.org/10.1117/12.2576804
Event: SPIE BiOS, 2021, Online Only
Abstract
Oral cavity and oropharyngeal cancers are leading pathologies, representing 3% of all new cancer cases in the United States. Adequate intraoperative marginal clearance of these malignancies is essential for long-term survival; however, presently available techniques limit precise instantaneous tumor margin characterization. Herein, we report the clinical validation of a fiber-based fluorescence lifetime imaging device for real-time intraoperative tumor delineation. Results from 72 human patients are reported (autofluorescence trends, ROC-AUC), including diverse cancer histologies, anatomic sites (e.g. tongue, tonsil, etc.), and patient medical histories. Emphasis is placed on results governing the detection of unknown primary tumors from 4 patients, as well as data from 5 patients presenting with residual carcinoma.
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Brent W. Weyers, Mark Marsden, Julien Bec, Takanori Fukazawa, Roberto P. Frusciante, Athena K. Tam, Dorina Gui, Andrew C. Birkeland, Marianne Abouyared, Arnaud F. Bewley, Regina F. Gandour-Edwards, John E. Hanks, D. Gregory Farwell, and Laura Marcu "Intraoperative FLIm for pathology detection and surgical guidance in oral and oropharyngeal cancer patients", Proc. SPIE 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, 116310V (5 March 2021); https://doi.org/10.1117/12.2576804
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KEYWORDS
Cancer
Pathology
Tumors
Luminescence
Tissues
Fluorescence lifetime imaging
Imaging devices
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