Quality assessment of diagnostic core-needle breast biopsy using structured illumination microscopy

Madeline Behr; Layla Alizadeh; Brett Roberts; Lyndsey Buckner Biamonte; J. Quincy Brown

doi:10.1117/12.2577809

5 March 2021 Quality assessment of diagnostic core-needle breast biopsy using structured illumination microscopy

Madeline Behr, Layla Alizadeh, Brett Roberts, Lyndsey Buckner Biamonte, J. Quincy Brown

Proceedings Volume 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 1163605 (2021) https://doi.org/10.1117/12.2577809
Event: SPIE BiOS, 2021, Online Only

Abstract

Structured illumination microscopy provides a compelling solution to location inaccuracy a in core-needle breast biopsy procedures. Fluorescent H and E analog dyes and dual-channel SIM imaging were utilized to create an digital pathology image analogous to a standard histology within minutes for point of care pathology. This study validated SIM’s ability to generate an image for on-site pathology validation of sample quality which minimizes the risk of a repeat procedure. Diagnoses from the diagnostic-quality SIM images were also proven to align with diagnoses obtained by standard histological processing of the same sample.

Conference Presentation

Citation Download Citation

Madeline Behr, Layla Alizadeh, Brett Roberts, Lyndsey Buckner Biamonte, and J. Quincy Brown "Quality assessment of diagnostic core-needle breast biopsy using structured illumination microscopy", Proc. SPIE 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1163605 (5 March 2021); https://doi.org/10.1117/12.2577809

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