Local optic axis imaging of human skin in vivo reveals collagen architecture in the dermis

Qingyun Li; David Sampson; Martin Villiger

doi:10.1117/12.2577843

5 March 2021 Local optic axis imaging of human skin in vivo reveals collagen architecture in the dermis

Qingyun Li, David Sampson, Martin Villiger

Proceedings Volume 11646, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics; 116460V (2021) https://doi.org/10.1117/12.2577843
Event: SPIE BiOS, 2021, Online Only

Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) measures the depth-dependent polarization states of light backscattered in tissue. We have developed algorithms for the robust reconstruction of the local, depth-resolved OAx orientation, which recursively compensate for the cumulative effect of the preceding tissue layers. Local OAx imaging in healthy human skin in vivo revealed dense, weaving patterns that are imperceptible in OCT intensity tomograms and that suggest a mesh-like tissue organization, consistent with the morphology of dermal collagen. Local OAx orientation as a contrast mechanism merits further exploration for applications in dermatology and in other tissues and organs presenting intrinsic birefringence contrast.

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Qingyun Li, David Sampson, and Martin Villiger "Local optic axis imaging of human skin in vivo reveals collagen architecture in the dermis", Proc. SPIE 11646, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics, 116460V (5 March 2021); https://doi.org/10.1117/12.2577843

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KEYWORDS

Collagen

Skin

Tissue optics

In vivo imaging

Tissues

Algorithm development

Optical coherence tomography

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