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5 March 2021 PRADA: portable reusable accurate diagnostics with nanostar antennas for multiplexed biomarker screening
Xiaona Wen, Rizia Bardhan
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Proceedings Volume 11651, Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics; 116510A (2021) https://doi.org/10.1117/12.2582007
Event: SPIE BiOS, 2021, Online Only
Abstract
Precise monitoring of specific biomarkers in biological fluids with accurate biodiagnostic sensors is critical for early diagnosis of diseases and subsequent treatment planning. In this work, we demonstrated an innovative biodiagnostic sensor, PRADA: portable reusable accurate diagnostics with nanostar antennas, for multiplexed biomarker detection in small volumes enabled in a microfluidic platform. Here, PRADA simultaneously detected two biomarkers of myocardial infarction, cardiac troponin I, which is well accepted for cardiac disorders, and neuropeptide Y, which controls cardiac sympathetic drive. We envision low-cost PRADA will have tremendous translational impact and amenable to resource-limited settings for accurate treatment planning in patients.
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Xiaona Wen and Rizia Bardhan "PRADA: portable reusable accurate diagnostics with nanostar antennas for multiplexed biomarker screening", Proc. SPIE 11651, Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics, 116510A (5 March 2021); https://doi.org/10.1117/12.2582007
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KEYWORDS
Antennas
Diagnostics
Multiplexing
Sensors
Microfluidics
Surface enhanced Raman spectroscopy
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