Rapid, non-destructive, and volumetric characterization of zebrafish tumor models using Jones-matrix optical coherence tomography

Antonia Lichtenegger; Pradipta Mukherjee; Lida Zhu; Shuichi Makita; Konrad Leskovar; Martin Distel; Yoshiaki Yasuno; Bernhard Baumann

doi:10.1117/12.2606982

7 March 2022 Rapid, non-destructive, and volumetric characterization of zebrafish tumor models using Jones-matrix optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Lida Zhu, Shuichi Makita, Konrad Leskovar, Martin Distel, Yoshiaki Yasuno, Bernhard Baumann

Author Affiliations +

Proceedings Volume 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; 119480D (2022) https://doi.org/10.1117/12.2606982
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The zebrafish is an essential animal model in pre-clinical research, especially in the field of cancer investigations. A polarization sensitive Jones matrix OCT (JM-OCT) prototype operating at 1310 nm was utilized to investigate adult control and tumor zebrafish models. Various anatomical features were characterized based on their inherent scattering and polarization properties. A motorized translation stage in combination with the prototype enabled large field-of-view imaging to investigate whole adult zebrafish non-destructively. The reflectivity, the attenuation coefficient and local polarization parameters such as the birefringence and the degree of polarization uniformity were analyzed to quantify differences in tumor versus control regions.

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Antonia Lichtenegger, Pradipta Mukherjee, Lida Zhu, Shuichi Makita, Konrad Leskovar, Martin Distel, Yoshiaki Yasuno, and Bernhard Baumann "Rapid, non-destructive, and volumetric characterization of zebrafish tumor models using Jones-matrix optical coherence tomography", Proc. SPIE 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, 119480D (7 March 2022); https://doi.org/10.1117/12.2606982

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