Experience with the liposomal delivery of the photosensitizer isoBoSiNc

Barbara W. Henderson; Eric Mayhew

doi:10.1117/12.17656

1 July 1990 Experience with the liposomal delivery of the photosensitizer isoBoSiNc

Barbara W. Henderson, Eric Mayhew

Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17656
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

The silicon naphthalocyanine isoBoSiNc was studied with regard to its photosensitizing properties when carried in the following vehicles: chreinophore, Tween 80 and liposoiaes of various composition. Encapsulation of the sensitizer in liposomes was complicated by the drug's tendency to aggregate, and was successful only at very high lipid: isoBoSiNc ratios. Encapsulation efficiency was low. Liposoinal delivery of the sensitizer in vivo did not seem to significantly improve the biologic response when compared to other vehicles.

Citation Download Citation

Barbara W. Henderson and Eric Mayhew "Experience with the liposomal delivery of the photosensitizer isoBoSiNc", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); https://doi.org/10.1117/12.17656

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