Waveguide Enhanced Raman Spectroscopy (WERS) for biomarker detection and identification

Nathan F. Tyndall; Dmitry A. Kozak; Marcel W. Pruessner; Todd H. Stievater; Benjamin L. Miller; P. Y. Wang; J. N. Butt

doi:10.1117/12.2623361

30 May 2022 Waveguide Enhanced Raman Spectroscopy (WERS) for biomarker detection and identification

Nathan F. Tyndall, Dmitry A. Kozak, Marcel W. Pruessner, Todd H. Stievater, Benjamin L. Miller, P. Y. Wang, J. N. Butt

Proceedings Volume 12116, Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XXIII; 121160F (2022) https://doi.org/10.1117/12.2623361
Event: SPIE Defense + Commercial Sensing, 2022, Orlando, Florida, United States

Abstract

The concentration of small molecule biomarkers in human serum and saliva has been shown to be characteristic of viral disease and correlated with disease severity. Inexpensive point-of-care diagnostic methods to quantify and track these analytes would provide additional information beyond viral or antibody detection assays to guide diagnosis and therapy. Waveguide-enhanced Raman spectroscopy (WERS) enables the detection and identification of trace concentrations of dissolved analytes using a chip-scale photonic circuit based on long evanescent waveguides. Here, we describe WERS measurements of two biomarkers: glucose and urea. This proof-of-concept work will provide the basis for the development of handheld bio-marker detection systems based on packaged photonic circuits integrated with a laser source and detector.

Conference Presentation

Citation Download Citation

Nathan F. Tyndall, Dmitry A. Kozak, Marcel W. Pruessner, Todd H. Stievater, Benjamin L. Miller, P. Y. Wang, and J. N. Butt "Waveguide Enhanced Raman Spectroscopy (WERS) for biomarker detection and identification", Proc. SPIE 12116, Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XXIII, 121160F (30 May 2022); https://doi.org/10.1117/12.2623361

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