Nowadays, researching and developing new wet adhesives have been a worldwide issue to be discussed since traditional adhesives lose their efficacy in wet environments due to a layer of water film on the surface and for which the demand for adhesives in the wet environment has increased dramatically. Among the researches, the mussel bionic adhesives are in a stage of rapid progress, giving a breakthrough direction from the perspective of bionics. In this article, wet adhesives are divided into two categories by chemical composition, i.e. catechol-based wet adhesives and non-catechol-based wet adhesives. Then researchers on which are reviewed, including their adhesive mechanism due to covalent bonds or noncovalent interactions, preparation as well as the biomedical application as tissues. This paper is aiming to provide a comprehensive understanding of wet adhesives, beginning with the fundamental problems of underwater adherence, along with synthetic approaches and bio-applications. These insights will provide rational directions for developing wet adhesive materials with improved adhesives performance and uncompromised adhesive qualities using nature's blueprints.
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