This study aims to optimize the ablation depth using a Ho:YAG laser and a waterjet. The results show that the maximum achieved depth for a 1 cm-long line cut was 0.86, 1.07, and 2.24 mm at energies of 500, 1000, and 2000 mJ/pulse, respectively. The line cuts were performed by translating the sample horizontally (back and forth) at the speed of 8 mm/s. After 120 s (~100 pulses/position), the depth achieved was saturated at all energy levels. As Ho:YAG lasers can be delivered through low-cost and flexible silica fibers, they have a great potential for endoscopic minimally invasive surgeries.
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