An automatic whole-slide hyperspectral imaging microscope

Minh Ha Tran; Ofelia Gomez; Baowei Fei

doi:10.1117/12.2650815

16 March 2023 An automatic whole-slide hyperspectral imaging microscope

Minh Ha Tran, Ofelia Gomez, Baowei Fei

Proceedings Volume 12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; 1239106 (2023) https://doi.org/10.1117/12.2650815
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Whole slide imaging (WSI) is a common step used in histopathology to quickly digitize stained histological slides. Digital whole-slide images not only improve the efficiency of labeling but also open the door for computer-aided diagnosis, specifically machine learning-based methods. Hyperspectral imaging (HSI) is an imaging modality that captures data in various wavelengths, some beyond the range of visible lights. In this study, we developed and implemented an automated microscopy system that can acquire hyperspectral whole slide images (HWSI). The system is robust since it consists of parts that can be swapped and bought from different manufacturers. We used the automated system and built a database of 49 HWSI of thyroid cancer. The automatic whole-slide hyperspectral imaging microscope can have many potential applications in biological and medical areas.

Conference Presentation

Citation Download Citation

Minh Ha Tran, Ofelia Gomez, and Baowei Fei "An automatic whole-slide hyperspectral imaging microscope", Proc. SPIE 12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, 1239106 (16 March 2023); https://doi.org/10.1117/12.2650815

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