IR780-based diffuse fluorescence tomography for cancer detection

Zhuanxia He; Limin Zhang; Lingxiu Xing; Wenjing Sun; Xiujun Gao; Yanqi Zhang; Feng Gao

doi:10.1117/12.2685617

27 November 2023 IR780-based diffuse fluorescence tomography for cancer detection

Zhuanxia He, Limin Zhang, Lingxiu Xing, Wenjing Sun, Xiujun Gao, Yanqi Zhang, Feng Gao

Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 127701L (2023) https://doi.org/10.1117/12.2685617
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Conference Poster

Abstract

IR780 is widely used as a commercially available near infrared contrast agent due to superior optical properties and tumor targeting capacity, while is a photosensitizer for photothermal (PTT) and photodynamic therapy (PDT). However, few articles reported the accumulation, dynamics and retention of IR780 in tumor. In the work, we explored the accumulation and retention of IR780 in tumor by quantitatively recovering the three-dimensional distributions of IR780 using a home-made diffuse fluorescence tomography (DFT) prototype system. The results showed that DFT can effectively identified multiple tumor targets with a significant tumor-to-normal-tissue ratio simultaneously. The kinetics of fluorescent signals in tumors and liver showed that IR780 was quickly cleared from the liver, whereas exhibited much higher tumor retention over 7days. Ex vivo imaging of dissected organs and fluorescence signal analysis revealed that IR780 was mainly concentrated in tumor and lung with significantly different from the distribution in other organs, suggesting that IR780 had excellent tumor homing ability.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Zhuanxia He, Limin Zhang, Lingxiu Xing, Wenjing Sun, Xiujun Gao, Yanqi Zhang, and Feng Gao "IR780-based diffuse fluorescence tomography for cancer detection", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 127701L (27 November 2023); https://doi.org/10.1117/12.2685617

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available