A Monte Carlo study for excitation field in Cherenkov-excited luminescence scanned tomography

Hu Zhang; Ting Hu; Zhe Li; Zhonghua Sun; Kebin Jia; Jinchao Feng

doi:10.1117/12.3001412

12 March 2024 A Monte Carlo study for excitation field in Cherenkov-excited luminescence scanned tomography

Hu Zhang, Ting Hu, Zhe Li, Zhonghua Sun, Kebin Jia, Jinchao Feng

Proceedings Volume 12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; 128250B (2024) https://doi.org/10.1117/12.3001412
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Cherenkov-Excited Luminescence Scanned Tomography (CELST) involves a system of coupled continuous wavedomain diffusion equations for modeling. The excitation field quantized by the Complex Cosine (CC) method effectively simulates the forward light process in these equations. However, when considering x-ray-induced Cherenkov light within biological tissue, the CC-based excitation field lacks precision, instead requires the use of stochastic Monte Carlo (MC) methods. To accurately describe the radiation-induced light transport in biological tissue and CELST image reconstruction, in this paper, we develop a MC-based method for CELST, named sheet Monte Carlo (sMC). Experiments show that the sMC field can achieve 11.47 on contrast-to-noise ratio (CNR) and 0.74 on Pearson correlation (PC), while 7.25 and 0.57 for the CC initialization field under 4% noise level. Furthermore, our results highlight that the proposed excitation field exhibits superior reconstruction performance, especially when dealing with low ratios of fluorescent targets.

Citation Download Citation

Hu Zhang, Ting Hu, Zhe Li, Zhonghua Sun, Kebin Jia, and Jinchao Feng "A Monte Carlo study for excitation field in Cherenkov-excited luminescence scanned tomography", Proc. SPIE 12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, 128250B (12 March 2024); https://doi.org/10.1117/12.3001412

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