Optical characterization of riboflavin as a potential biomarker in the diagnosis of cervical cancer

Ramu Rajasekaran; Elumalai Brindha; Ganesan Bharanidharan; Biniyam Girma Manaye; Prakasarao Aruna; Singaravelu Ganesan

doi:10.1117/12.3010046

12 March 2024 Optical characterization of riboflavin as a potential biomarker in the diagnosis of cervical cancer

Ramu Rajasekaran, Elumalai Brindha, Ganesan Bharanidharan, Biniyam Girma Manaye, Prakasarao Aruna, Singaravelu Ganesan

Proceedings Volume 12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 128360H (2024) https://doi.org/10.1117/12.3010046
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Urine is one of the diagnostically important bio fluids, as it has many metabolites and some of them are native fluorophores. Riboflavin and its cofactors FMN and FAD which act as electron carriers participates in a diversity of redox reactions central to human metabolism. It has been reported that riboflavin plays a prominent role in progression of various cancers. It is well documented that, the fluorophore flavins that is not bound to proteins in the plasma is filtered by glomerulus and excreted in urine. Fluorescence spectroscopy has been considered as a promising tool to characterize the riboflavin present in the urine. The overall spectral data at 450 nm excitation were subjected to principal components based linear discriminant analysis. As a result, 100 % of the normal subjects and 90% of the cervical cancer subjects were correctly classified which shows that there exists significant difference between them.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Ramu Rajasekaran, Elumalai Brindha, Ganesan Bharanidharan, Biniyam Girma Manaye, Prakasarao Aruna, and Singaravelu Ganesan "Optical characterization of riboflavin as a potential biomarker in the diagnosis of cervical cancer", Proc. SPIE 12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 128360H (12 March 2024); https://doi.org/10.1117/12.3010046

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