Photoacoustic imaging of colorectal cancer in ex vivo samples: a preliminary study

Ashkan Ghanbarzadeh-Dagheyan; Kalloor Joseph Francis; Cyrille Mooij; Stefan van der Stel; Mithun Kuniyil Ajith Singh; Theo Ruers

doi:10.1117/12.3002767

12 March 2024 Photoacoustic imaging of colorectal cancer in ex vivo samples: a preliminary study

Ashkan Ghanbarzadeh-Dagheyan, Kalloor Joseph Francis, Cyrille Mooij, Stefan van der Stel, Mithun Kuniyil Ajith Singh, Theo Ruers

Author Affiliations +

Proceedings Volume 12842, Photons Plus Ultrasound: Imaging and Sensing 2024; 1284214 (2024) https://doi.org/10.1117/12.3002767
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Colorectal cancer claimed nearly 1 million lives in 2022. According to World Health Organization, the prevalence and mortality rates of this disease are on the rise in the world, mainly due to an unhealthy diet, low in fiber. Recently, neoadjuvant therapy, which is a combination of chemo- and radiotherapy, has gained more attention over radical surgery for responsive patients. This is because if the patient responds excellently to neoadjuvant therapy, through monitoring, radical surgery could be avoided, saving the patient’s organ and bettering their quality of life. However, presently, monitoring is limited using MRI and colonoscopy, making decisions about the patient’s status difficult after therapy. New modalities such as photoacoustic (PA) imaging may help improve the monitoring by distinguishing between malignant and healthy or fibrotic tissue. In this work, we carry out a preliminary study on the use of LED-based PA imaging on colorectal samples ex vivo, in a preclinical setting. Our analysis shows that the PA image intensity is lower in the malignant tissue than the fatty tissue. However, our results are inconclusive about the difference between tumor and healthy colorectal tissue due to limited data and the effect of depth on the PA signal. For future research, collecting more data and the use of a tunable laser source are recommended.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Ashkan Ghanbarzadeh-Dagheyan, Kalloor Joseph Francis, Cyrille Mooij, Stefan van der Stel, Mithun Kuniyil Ajith Singh, and Theo Ruers "Photoacoustic imaging of colorectal cancer in ex vivo samples: a preliminary study", Proc. SPIE 12842, Photons Plus Ultrasound: Imaging and Sensing 2024, 1284214 (12 March 2024); https://doi.org/10.1117/12.3002767

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