Effects of MRI parameters on the shifted apparent diffusion coefficient in an abdominal phantom

Wedyan Aldarrab; Abdullah Abujamea; Ashwag Alruwaili; Mohammed Almousa; Malak Aleliwah; Faisal Fakhouri; Lina Hammad; Elaine Harkness; Susan Astley; Richard Hodgson; William Lloyd

doi:10.1117/12.3006584

1 April 2024 Effects of MRI parameters on the shifted apparent diffusion coefficient in an abdominal phantom

Wedyan Aldarrab, Abdullah Abujamea, Ashwag Alruwaili, Mohammed Almousa, Malak Aleliwah, Faisal Fakhouri, Lina Hammad, Elaine Harkness, Susan Astley, Richard Hodgson, William Lloyd

Author Affiliations +

Proceedings Volume 12925, Medical Imaging 2024: Physics of Medical Imaging; 129254C (2024) https://doi.org/10.1117/12.3006584
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Conference Poster

Abstract

Shifted apparent diffusion coefficient (sADC) is an alternative to magnetic resonance elastography for calculating liver stiffness virtually, without the use of special elasticity software/hardware. The aim of this work was to investigate the effects of changing repetition time (TR), echo time (TE) and number of excitations (NEX) on sADC quantification using an abdominal phantom. Diffusion weighted images with b-values of 0, 200, and 1500 s/mm2 were acquired at 1.5T using a fat-suppressed spin echo sequence with varying TR (1 to 16s), TE (75 to 90ms) and NEX (4 to 12). ADC maps were generated by the scanner and sADC maps were calculated from the b=200 and b=1500 diffusion weighted images. Regions of interest were selected in the phantom liver parenchyma and lesion. Percent difference was calculated for each variable as [(Maximum-Minimum)/Maximum]*100. The session was performed 5 times and the mean ADC/sADC for each variable across each session was used to calculate the between-session percent difference. At TR>5000ms the percent difference in ADC and sADC was generally less within a session than between sessions. At TR<5000ms, ADC increased initially with TR. For NEX and TE, percent difference between sessions was generally greater than percent difference within sessions. This phantom study showed little obvious effect of varying TR (when TR>5000ms), NEX or TE on ADC or sADC compared to the differences between sessions with the MR protocol used.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Wedyan Aldarrab, Abdullah Abujamea, Ashwag Alruwaili, Mohammed Almousa, Malak Aleliwah, Faisal Fakhouri, Lina Hammad, Elaine Harkness, Susan Astley, Richard Hodgson, and William Lloyd "Effects of MRI parameters on the shifted apparent diffusion coefficient in an abdominal phantom", Proc. SPIE 12925, Medical Imaging 2024: Physics of Medical Imaging, 129254C (1 April 2024); https://doi.org/10.1117/12.3006584

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