Noninvasive measurement of regional cerebrovascular oxygen saturation in humans using optical spectroscopy

Patrick W. McCormick; Mick Stewart; Gary D. Lewis

doi:10.1117/12.44200

1 May 1991 Noninvasive measurement of regional cerebrovascular oxygen saturation in humans using optical spectroscopy

Patrick W. McCormick, Mick Stewart, Gary D. Lewis

Proceedings Volume 1431, Time-Resolved Spectroscopy and Imaging of Tissues; (1991) https://doi.org/10.1117/12.44200
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Noninvasive diffuse IR transmission spectroscopy is used to measure the attenuation of hemoglobin in the human cerebrovasculature. Experimental data demonstrating the intracranial, cerebrovascular source of the IR signal is presented. An algorithm to quantify per-cent hemoglobin oxygen saturation in the brain from these transmission spectra is outlined. The spectroscopic cerebrovascular hemoglobin saturation measured correlates well with the best clinical reference measurement of brain hemoglobin saturation (n equals 68, r equals 0.74, s equals 3.5), and IR spectroscopy is more sensitive to reduced brain oxygen than analogue or processed electroencephalography (EEG) data (p < .05).

Citation Download Citation

Patrick W. McCormick, Mick Stewart, and Gary D. Lewis "Noninvasive measurement of regional cerebrovascular oxygen saturation in humans using optical spectroscopy", Proc. SPIE 1431, Time-Resolved Spectroscopy and Imaging of Tissues, (1 May 1991); https://doi.org/10.1117/12.44200

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